The five primary Panchakarma therapies—Vamana, Virechana, Basti, Nasya, and Raktamokshana is a scientific way of detoxification and systemic modulation. These interventions facilitate targeted elimination of metabolic toxins (Ama), optimize hepatic, renal, gastrointestinal, and lymphatic function, and restore dosha-specific physiological equilibrium. These therapies enhance microcirculation, neuroendocrine regulation, and autonomic nervous system balance, reduce oxidative stress and systemic inflammation, and modulate the gut-brain axis. By simultaneously addressing metabolic, neuromuscular, and psychosomatic dysfunctions, Panchakarma provides a comprehensive therapeutic framework for improving organ system efficiency, cognitive function, and holistic health.